Synthesis and Antitumor Activity of Polyphosphazene/Methoxy-Poly(ethylene glycol)/(Diamine)platinum(II) Conjugates

Synthesis and Antitumor Activity of Poly(organophosphazene)/ Doxorubicin Conjugates

Doxorubicin shows a wide spectrum of activity for solid tumors such as sarcomas, adenocarcinomas and melanomas, but its strong side effects including myelosuppression, extravasation reaction and cardiotoxicity have been a serious problem.1 Polymer-anticancer drug conjugates have been studied in order to improve the side effects of the anticancer drugs. In comparison with low-molecular weight an...

Synthesis and Study of Antitumor Activity of Substituted Imidazolecarboxamides

      In view of potential biological activities of small molecule polyamides, we synthesized some novel N-(2-aminoethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamide (7a,b), and N-(2-(1-benzyl-2-(alkylthio) -1H-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-1H-imidazole-5-carboxamides (8a,b) as antitumor agents. The antitumor activity of compounds 7a,b and 8a,b was studied at c...

Daunomycin-polypeptide conjugates with antitumor activity.

We have developed a group of water-soluble drug conjugates in which daunomycin (Dau) is coupled to cationic, amphoteric or anionic branched polypeptides and a new conjugate containing a cationic polypeptide carrier modified with a cell penetrating octaarginine. We investigated in vitro physiological activity of these conjugates in several aspects: in vitro cytotoxicity and cytostatic effect, ad...

Synthesis and in vitro antitumor effect of peptide - drug conjugates

comparison of catalytic activity of heteropoly compounds in the synthesis of bis(indolyl)alkanes.

heteropoly acids (hpa) and their salts have advantages as catalysts which make them both economically and environmentally attractive, strong br?nsted acidity, exhibiting fast reversible multi-electron redox transformations under rather mild conditions, very high solubility in polar solvents, fairly high thermal stability in the solid states, and efficient oxidizing ability, so that they are imp...